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At full dose of 50mg to 150mg per day naltrexone is used for opiate addiction.

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In an uncontrolled cohort study, Miotto and colleagues reported that 81 patients who were receiving naltrexone for opioid dependence exhibited higher than expected rates of overdose and suicide.

Topics covered in this review include the history and demographics of illicit and prescription opioid abuse; risk factors, background characteristics, and comorbid conditions of opioid abusers; the pharmacology of opioid drugs; the biological and behavioral characteristics of opioid dependence; and management of opioid dependence, including treatment of overdose, detoxification and withdrawal, agonist replacement therapy, and drug-free approaches.

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