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Topics covered in this review include the history and demographics of illicit and prescription opioid abuse; risk factors, background characteristics, and comorbid conditions of opioid abusers; the pharmacology of opioid drugs; the biological and behavioral characteristics of opioid dependence; and management of opioid dependence, including treatment of overdose, detoxification and withdrawal, agonist replacement therapy, and drug-free approaches.
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Reversing this trend is important because participation by the couple and family in social and recreational activities improves substance abuse treatment outcomes ().
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The cholinergic muscarinic 2 receptor has been associated with the function of memory and cognition, but has also been shown to be related to alcohol dependence and major depressive syndrome.
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